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Article

PICK1 uncoupling from mGluR7a causes absence-like seizures.

Nature neuroscience - 1 Aug 2008

Bertaso Federica, Zhang Chuansheng, Scheschonka Astrid, de Bock Frédéric, Fontanaud Pierre, Marin Philippe, Huganir Richard L, Betz Heinrich, Bockaert Joël, Fagni Laurent, Lerner-Natoli Mireille

Abstract excerpt

Absence epilepsy is a neurological disorder that causes a recurrent loss of consciousness and generalized spike-and-wave discharges on an electroencephalogram (EEG). The role of metabotropic glutamate receptors (mGluRs) and associated scaffolding proteins in absence epilepsy has been unclear to date. We investigated a possible role for these proteins in absence epilepsy, focusing on the mGluR7a receptor and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18641645
DOI: 10.1038/nn.2142
PMCID: PMC2764992

Genes

PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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PICK1 uncoupling from mGluR7a causes absence-like seizures.PMID 18641645Read ↗

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