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S-adenosylhomocysteine hydrolase downregulation contributes to tumorigenesis

19 Aug 2008

Abstract excerpt

With the idea to discover novel genes involved in proliferation, we have performed a genome-wide loss-of-function genetic screen to identify additional putative tumor suppressor genes. We have previously identified five genes belonging to different biochemical families. In this report, we focused on the study of one of these genes designated S-adenosylhomocysteine hydrolase (SAHH), which has also been previously...

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PMID: 18713839
DOI: 10.1093/carcin/bgn198

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