Article
Depletion of runt-related transcription factor 2 (RUNX2) enhances SAHA sensitivity of p53-mutated pancreatic cancer cells through the regulation of mutant p53 and TAp63.
PloS one - 1 Jan 2017
Ogata Takehiro, Nakamura Mizuyo, Sang Meijie, Yoda Hiroyuki, Hiraoka Kiriko, Yin Danjing, Sang Mexiang, Shimozato Osamu, Ozaki Toshinori
Abstract excerpt
Suberoylanilide hydroxamic acid (SAHA) represents one of the new class of anti-cancer drugs. However, multiple lines of clinical evidence indicate that SAHA might be sometimes ineffective on certain solid tumors including pancreatic cancer. In this study, we have found for the first time that RUNX2/mutant p53/TAp63-regulatory axis has a pivotal role in the determination of SAHA sensitivity of p53-mutated...
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