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Autophagy induced by SAHA affects mutant P53 degradation and cancer cell survival

1 Feb 2019

Abstract excerpt

gene produce mutant p53 (mutp53) proteins which may acquire oncogenic properties favoring chemoresistance, cell migration, and metastasis. The exploitation of cellular pathways that promote mutp53 degradation may reduce cell proliferation and invasion as well as increase the sensitivity to anticancer drugs, with a strong impact on current cancer therapies. In the last years, several molecules have been...

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PMID: 30745455
DOI: 10.1042/bsr20181345

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