Article
The RNA binding protein CsrA controls cyclic di-GMP metabolism by directly regulating the expression of GGDEF proteins.
Molecular microbiology - 1 Oct 2008
Jonas Kristina, Edwards Adrianne N, Simm Roger, Romeo Tony, Römling Ute, Melefors Ojar
Abstract excerpt
The carbon storage regulator CsrA is an RNA binding protein that controls carbon metabolism, biofilm formation and motility in various eubacteria. Nevertheless, in Escherichia coli only five target mRNAs have been shown to be directly regulated by CsrA at the post-transcriptional level. Here we identified two new direct targets for CsrA, ycdT and ydeH, both of which encode proteins with GGDEF domains. A csrA...
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