Article
CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli.
Molecular microbiology - 1 Jun 2002
Baker Carol S, Morozov Igor, Suzuki Kazushi, Romeo Tony, Babitzke Paul
Abstract excerpt
The carbon storage regulatory system of Escherichia coli controls the expression of genes involved in carbohydrate metabolism and cell motility. CsrA binding to glgCAP transcripts inhibits glycogen metabolism by promoting glgCAP mRNA decay. CsrB RNA functions as an antagonist of CsrA by sequestering this protein and preventing its action. In this paper, we elucidate further the mechanism of CsrA-mediated glgC...
Topics
- 5' Untranslated Regions
- Electrophoretic Mobility Shift Assay
- Escherichia coli
- Escherichia coli Proteins
- Genes, Regulator
- Glucose-1-Phosphate Adenylyltransferase
- Glycogen
- Models, Genetic
- Mutation
- Nucleotidyltransferases
- Protein Biosynthesis
- RNA-Binding Proteins
- Repressor Proteins
- Sequence Deletion
- Transcription, Genetic