Article
Genome-wide transcriptional profile of Escherichia coli in response to high levels of the second messenger 3',5'-cyclic diguanylic acid.
The Journal of biological chemistry - 24 Mar 2006
Méndez-Ortiz M Marcela, Hyodo Mamoru, Hayakawa Yoshihiro, Membrillo-Hernández Jorge
Abstract excerpt
Cyclic diguanylic acid (c-di-GMP; cGpGp) is a global second messenger controlling motility and adhesion in bacterial cells. Intracellular concentrations of c-di-GMP depend on two opposite activities: diguanylate cyclase, recently assigned to the widespread GGDEF domain, and c-di-GMP-specific phosphodiesterase, associated with proteins harboring the EAL domain. To date, little is known about the targets of...
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