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Article

The Legionella pneumophila genome evolved to accommodate multiple regulatory mechanisms controlled by the CsrA-system.

PLoS genetics - 1 Feb 2017

Sahr Tobias, Rusniok Christophe, Impens Francis, Oliva Giulia, Sismeiro Odile, Coppée Jean-Yves, Buchrieser Carmen

Abstract excerpt

The carbon storage regulator protein CsrA regulates cellular processes post-transcriptionally by binding to target-RNAs altering translation efficiency and/or their stability. Here we identified and analyzed the direct targets of CsrA in the human pathogen Legionella pneumophila. Genome wide transcriptome, proteome and RNA co-immunoprecipitation followed by deep sequencing of a wild type and a csrA mutant strain...

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Identifiers

PMID: 28212376
DOI: 10.1371/journal.pgen.1006629
PMCID: PMC5338858

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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