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Article

Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma.

1 Oct 2008

Abstract excerpt

The retinoblastoma protein-interacting zinc finger gene RIZ1 is a putative tumor suppressor gene, and the inactivation of the RIZ1 is frequently found in tumors through a loss of mRNA expression. In order to understand the role of RIZ1 inactivation in the tumorigenesis of hepatocellular carcinoma (HCC), we detected the RIZ1 promoter methylation status in 39 HCCs using a methylation specific PCR (MSP) method, and...

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PMID: 18712668
DOI: 10.14670/hh-23.1171

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Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma.PMID 18712668Read ↗

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The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancersSemantic proximity Read ↗

Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype.Semantic proximity Read ↗

HBx represses RIZ1 expression by DNA methyltransferase 1 involvement in decreased miR-152 in hepatocellular carcinomaSemantic proximity Read ↗

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RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.Semantic proximity Read ↗

Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesisSemantic proximity Read ↗

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