Article
Genetic polymorphisms in the Rb-binding zinc finger gene RIZ and the risk of lung cancer.
Carcinogenesis - 1 Sept 2007
Yoon Kyong-Ah, Park Sohee, Hwangbo Bin, Shin Hyoung Doo, Cheong Hyun Sub, Shin Hai-Rim, Lee Jin Soo
Abstract excerpt
Histone methyltransferase (HMT) enzymes that methylate the lysine of histones are involved in chromatin-mediated gene expression. Previously, we reported that a novel polymorphism of SUV39H2, the HMT that is required for the methylation of H3-K9, was associated with an increased risk of lung cancer in Koreans. The retinoblastoma protein-interacting zinc finger gene RIZ (PRDM2) is also a member of a...
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