Article
Preferential loss of a polymorphic RIZ allele in human hepatocellular carcinoma.
British journal of cancer - 23 Mar 2001
Fang W, Piao Z, Buyse I M, Simon D, Sheu J C, Perucho M, Huang S
Abstract excerpt
The RIZ (PRDM2) locus commonly undergoes loss of heterozygosity (LOH) and maps within the minimal deleted region on 1p36 in hepatocellular carcinoma (HCC). Although peptide-altering mutations of RIZ are rare in HCC, the RIZ1 product is commonly lost in HCC and has tumour suppressive activities. Here, we analysed RIZ gene mutations and LOH in HCC, breast cancer, familial melanoma, colon cancer, and stomach cancer....
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