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Article

Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.

Genes & development - 1 Sept 2001

Steele-Perkins G, Fang W, Yang X H, Van Gele M, Carling T, Gu J, Buyse I M, Fletcher J A, Liu J, Bronson R, Chadwick R B, de la Chapelle A, Zhang X, Speleman F, Huang S

Abstract excerpt

The retinoblastoma protein-interacting zinc finger gene RIZ (PRDM2) is a member, by sequence homology, of a nuclear protein-methyltransferase (MTase) superfamily involved in chromatin-mediated gene expression. The gene produces two protein products, RIZ1 that contains a conserved MTase domain and...

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Source

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Identifiers

PMID: 11544182
DOI: 10.1101/gad.870101
PMCID: PMC312773

Genes

PRDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11544182-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.PMID 11544182Read ↗

Genetic polymorphisms in the Rb-binding zinc finger gene RIZ and the risk of lung cancer.Semantic proximity Read ↗

The retinoblastoma protein-interacting zinc finger gene RIZ in 1p36-linked cancersSemantic proximity Read ↗

Frequent epigenetic inactivation of RIZ1 by promoter hypermethylation in human gastric carcinoma.Semantic proximity Read ↗

RIZ, the retinoblastoma protein interacting zinc finger gene, is mutated in genetically unstable cancers of the pancreas, stomach, and colorectum.Semantic proximity Read ↗

Biallelic inactivation of the RIZ1 gene in human gastric cancer.Semantic proximity Read ↗

Frequent frameshift mutations of RIZ in sporadic gastrointestinal and endometrial carcinomas with microsatellite instability.Semantic proximity Read ↗

Candidate tumor suppressor RIZ is frequently involved in colorectal carcinogenesisSemantic proximity Read ↗

siRNA-based Therapeutic Candidate Targeting PRDM2 for Inhibition of Lung Cancer ProgressionSemantic proximity Read ↗

Mapping of a minimal deleted region in human hepatocellular carcinoma to 1p36.13-p36.23 and mutational analysis of the RIZ (PRDM2) gene localized to the region.Semantic proximity Read ↗

The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein.Semantic proximity Read ↗

Aberrant methylation and decreased expression of the RIZ1 gene are frequent in adult acute lymphoblastic leukemia of T-cell phenotype.Semantic proximity Read ↗

Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma.Semantic proximity Read ↗

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