Article
Tumor formation and inactivation of RIZ1, an Rb-binding member of a nuclear protein-methyltransferase superfamily.
Genes & development - 1 Sept 2001
Steele-Perkins G, Fang W, Yang X H, Van Gele M, Carling T, Gu J, Buyse I M, Fletcher J A, Liu J, Bronson R, Chadwick R B, de la Chapelle A, Zhang X, Speleman F, Huang S
Abstract excerpt
The retinoblastoma protein-interacting zinc finger gene RIZ (PRDM2) is a member, by sequence homology, of a nuclear protein-methyltransferase (MTase) superfamily involved in chromatin-mediated gene expression. The gene produces two protein products, RIZ1 that contains a conserved MTase domain and RIZ2 that lacks the domain. RIZ1 gene expression is frequently silenced in human cancers, and the gene is also a...
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