Article
Biallelic inactivation of the RIZ1 gene in human gastric cancer.
Oncogene - 9 Oct 2003
Tokumaru Yutaka, Nomoto Shuji, Jerónimo Carmen, Henrique Rui, Harden Susan, Trink Barry, Sidransky David
Abstract excerpt
The distal short arm of chromosome 1 is commonly deleted in a variety of human neoplasms including gastrointestinal cancer. Genetic alterations of the retinoblastoma protein-interacting zing-finger gene (RIZ)1 including loss of heterozygosity (LOH) at 1p36, frameshift mutations, and promoter hypermethylation were reported previously in several cancers. In this study, we evaluated RIZ1 in 30 primary gastric...
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