Article
Association of O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation with p53 mutation occurrence in non-small cell lung cancer with different histology, gender, and smoking status.
Annals of surgical oncology - 1 Nov 2008
Wu Jeng-Yuan, Wang John, Lai Ji-Ching, Cheng Ya-Wen, Yeh Kun-Tu, Wu Tzu-Chin, Chen Chih-Yi, Lee Huei
Abstract excerpt
BACKGROUND: O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation has been demonstrated to associate with the G:C-->A:T transition mutation in the p53 gene of lung tumors. The purpose of this study is to clarify whether MGMT promoter methylation is not only associated with the shift from the G:C-->A:T mutation in the p53 gene but also whether MGMT increases other mutation patterns in lung tumors....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.