Article
TP53 mutations in nonsmall cell lung cancer.
Journal of biomedicine & biotechnology - 1 Jan 2011
Mogi Akira, Kuwano Hiroyuki
Abstract excerpt
The tumor suppressor gene TP53 is frequently mutated in human cancers. Abnormality of the TP53 gene is one of the most significant events in lung cancers and plays an important role in the tumorigenesis of lung epithelial cells. Human lung cancers are classified into two major types, small cell lung cancer (SCLC) and nonsmall cell lung cancer (NSCLC). The latter accounts for approximately 80% of all primary lung...
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