Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.

The EMBO journal - 2 Dec 2002

Kuribayashi Futoshi, Nunoi Hiroyuki, Wakamatsu Kaori, Tsunawaki Shohko, Sato Kazuki, Ito Takashi, Sumimoto Hideki

Abstract excerpt

Activation of the superoxide-producing phagocyte NADPH oxidase, crucial in host defense, requires the cytosolic proteins p67(phox) and p47(phox). They translocate to the membrane upon cell stimulation and activate flavocytochrome b(558), the membrane-integrated catalytic core of this enzyme system. The activators p67(phox) and p47(phox) form a ternary complex together with p40(phox), an adaptor protein with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to GTP Phosphohydrolases
Share to NADPH Oxidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phagocytes

Share to Phosphoproteins

Share to Protein Transport

Share to rac GTP-Binding Proteins

Share to Receptors, Muscarinic

Share to Superoxides

Source

Open in PubMed Open full text

Identifiers

PMID: 12456638
DOI: 10.1093/emboj/cdf642
PMCID: PMC136946

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.PMID 12456638Read ↗

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.Semantic proximity Read ↗

Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production.Semantic proximity Read ↗

Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.Semantic proximity Read ↗

p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox.Semantic proximity Read ↗

Fc gamma R-stimulated activation of the NADPH oxidase: phosphoinositide-binding protein p40phox regulates NADPH oxidase activity after enzyme assembly on the phagosome.Semantic proximity Read ↗

The phosphoinositide-binding protein p40phox activates the NADPH oxidase during FcgammaIIA receptor-induced phagocytosis.Semantic proximity Read ↗

Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox).Semantic proximity Read ↗

Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases.Semantic proximity Read ↗

The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1.Semantic proximity Read ↗

The Nox Family of NAD(P)H Oxidases: Host Defense and BeyondSemantic proximity Read ↗

Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.Semantic proximity Read ↗

Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.