Article
p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox.
FEBS letters - 18 Sept 2007
Tamura Minoru, Shiozaki Iichiro, Ono Shohei, Miyano Kei, Kunihiro Sachio, Sasaki Takayuki
Abstract excerpt
p40(phox) activated phagocyte NADPH oxidase without p47(phox) in a cell-free system consisting of p67(phox), Rac and cytochrome b(558) relipidated with phosphatidylinositol 3-phosphate. The activation reached to 70% of that by p47(phox). Addition of p47(phox) slightly increased the activation, but not additively. p40(phox) improved the efficiency of p67(phox) in the activation. The C-terminus-truncated p67(phox),...
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