p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox.

doi:10.1016/j.febslet.2007.08.040

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Article

p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox.

FEBS letters - 18 Sept 2007

Tamura Minoru, Shiozaki Iichiro, Ono Shohei, Miyano Kei, Kunihiro Sachio, Sasaki Takayuki

Abstract excerpt

p40(phox) activated phagocyte NADPH oxidase without p47(phox) in a cell-free system consisting of p67(phox), Rac and cytochrome b(558) relipidated with phosphatidylinositol 3-phosphate. The activation reached to 70% of that by p47(phox). Addition of p47(phox) slightly increased the activation, but not additively. p40(phox) improved the efficiency of p67(phox) in the activation. The C-terminus-truncated p67(phox),...

Topics

Amino Acid Sequence
Animals
Blotting, Far-Western
Cattle
Cell-Free System
Enzyme Activation
Membrane Glycoproteins
Molecular Sequence Data
Mutation
NADPH Oxidases
Phosphoproteins
Protein Binding
Sequence Homology, Amino Acid
Sodium Dodecyl Sulfate
src Homology Domains

Source

Open in PubMed

Identifiers

PMID: 17803994
DOI: 10.1016/j.febslet.2007.08.040

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