Article
Interleukin-4 alters early phagosome phenotype by modulating class I PI3K dependent lipid remodeling and protein recruitment.
PloS one - 1 Jan 2011
de Keijzer Sandra, Meddens Marjolein B M, Kilic Dilek, Joosten Ben, Reinieren-Beeren Inge, Lidke Diane S, Cambi Alessandra
Abstract excerpt
Phagocytosis is a complex process that involves membranelipid remodeling and the attraction and retention of key effector proteins. Phagosome phenotype depends on the type of receptor engaged and can be influenced by extracellular signals. Interleukin 4 (IL-4) is a cytokine that induces the alternative activation of macrophages (MΦs) upon prolonged exposure, triggering a different cell phenotype that has an...
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