Article
Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.
The Journal of biological chemistry - 25 Nov 2011
Ueyama Takehiko, Nakakita Junya, Nakamura Takashi, Kobayashi Takeshi, Kobayashi Toshihiro, Son Jeonghyun, Sakuma Megumi, Sakaguchi Hirofumi, Leto Thomas L, Saito Naoaki
Abstract excerpt
During activation of the phagocyte (Nox2-based) NADPH oxidase, the cytoplasmic Phox complex (p47(phox)-p67(phox)-p40(phox)) translocates and associates with the membrane-spanning flavocytochrome b(558). It is unclear where (in cytoplasm or on membranes), when (before or after assembly), and how p40(phox) acquires its PI(3)P-binding capabilities. We demonstrated that in addition to conformational changes induced...
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