Article
Lunatic fringe protein processing by proprotein convertases may contribute to the short protein half-life in the segmentation clock.
Biochimica et biophysica acta - 1 Dec 2008
Shifley Emily T, Cole Susan E
Abstract excerpt
During vertebrate segmentation, oscillatory activation of Notch signaling is important in the clock that regulates the timing of somitogenesis. In mice, the cyclic activation of NOTCH1 requires the periodic expression of Lunatic fringe (Lfng). For LFNG to play a role in the segmentation clock, its cyclic transcription must be coupled with post-translational mechanisms that confer a short protein half-life. LFNG...
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