Derivatives of Moloney murine sarcoma virus capable of being transcribed in embryonal carcinoma stem cells have gained a functional Sp1 binding site.

doi:10.1128/JVI.65.4.1803-1811.1991

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Article

Derivatives of Moloney murine sarcoma virus capable of being transcribed in embryonal carcinoma stem cells have gained a functional Sp1 binding site.

Journal of virology - 1 Apr 1991

Prince V E, Rigby P W

Abstract excerpt

The long terminal repeat (LTR) sequences of Moloney murine leukemia virus and its closely related derivative Moloney murine sarcoma virus (Mo-MSV) are incapable of directing transcription in embryonal carcinoma (EC) stem cells. The myeloproliferative sarcoma virus, a derivative of Mo-MSV, has several point mutations in the LTR and is transcribed more efficiently to allow productive infection of F9 EC cells. One...

Topics

Base Sequence
Binding Sites
Cell Adhesion
Chloramphenicol O-Acetyltransferase
Consensus Sequence
DNA, Viral
Embryonal Carcinoma Stem Cells
Gene Expression
Leukemia Virus, Murine
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Moloney murine sarcoma virus

Mutation

Neoplastic Stem Cells

RNA, Viral

Repetitive Sequences, Nucleic Acid

Sp1 Transcription Factor

Teratoma

Source

Open in PubMed Open full text

Identifiers

PMID: 1848307
DOI: 10.1128/JVI.65.4.1803-1811.1991
PMCID: PMC239988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1848307-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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