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Article

Catalytic activity of nuclear PLC-beta(1) is required for its signalling function during C2C12 differentiation.

Cellular signalling - 1 Nov 2008

Ramazzotti Giulia, Faenza Irene, Gaboardi Gian Carlo, Piazzi Manuela, Bavelloni Alberto, Fiume Roberta, Manzoli Lucia, Martelli Alberto M, Cocco Lucio

Abstract excerpt

Here we report that PLC-beta(1) catalytic activity plays a role in the increase of cyclin D3 levels and induces the differentiation of C2C12 skeletal muscle cells. PLC-beta(1) mutational analysis revealed the importance of His(331) and His(378) for the catalysis. The expression of PLC-beta(1) and cyclin D3 proteins is highly induced during the process of skeletal myoblast differentiation. We have previously shown...

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PMID: 18694821
DOI: 10.1016/j.cellsig.2008.07.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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