Article
Cyclin D3 promotes adipogenesis through activation of peroxisome proliferator-activated receptor gamma.
Molecular and cellular biology - 1 Nov 2005
Sarruf David A, Iankova Irena, Abella Anna, Assou Said, Miard Stéphanie, Fajas Lluis
Abstract excerpt
In addition to their role in cell cycle progression, new data reveal an emerging role of D-type cyclins in transcriptional regulation and cellular differentiation processes. Using 3T3-L1 cell lines to study adipogenesis, we observed an up-regulation of cyclin D3 expression throughout the differentiation process. Surprisingly, cyclin D3 was only minimally expressed during the initial stages of adipogenesis, when...
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