Article
Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors.
The Journal of cell biology - 18 Aug 2003
Hribal Marta L, Nakae Jun, Kitamura Tadahiro, Shutter John R, Accili Domenico
Abstract excerpt
Insulin-like growth factors promote myoblast differentiation through phosphoinositol 3-kinase and Akt signaling. Akt substrates required for myogenic differentiation are unknown. Forkhead transcription factors of the forkhead box gene, group O (Foxo) subfamily are phosphorylated in an insulin-res...
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