Article
Functional expression and analysis of the pancreatic transcription factor PDX-1 in yeast.
Biochemical and biophysical research communications - 19 Jul 2002
Ozcan Sabire, Mosley Amber L, Aryal Bishwa K
Abstract excerpt
The pancreas-specific transcription factor Pdx-1 is important for pancreas development and beta-cell specific gene expression in insulin-producing cells. We have expressed the mouse PDX-1 gene in the yeast Saccharomyces cerevisiae and characterized its functional domains. Pdx-1 functions as a strong activator in yeast and stimulates gene expression by more than 80-fold. The transcriptional activation domain of...
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