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Article

A role for nuclear phospholipase Cbeta 1 in cell cycle control.

The Journal of biological chemistry - 29 Sept 2000

Faenza I, Matteucci A, Manzoli L, Billi A M, Aluigi M, Peruzzi D, Vitale M, Castorina S, Suh P G, Cocco L

Abstract excerpt

Phosphoinositide signaling resides in the nucleus, and among the enzymes of the cycle, phospholipase C (PLC) appears as the key element both in Saccharomyces cerevisiae and in mammalian cells. The yeast PLC pathway produces multiple inositol polyphosphates that modulate distinct nuclear processes. The mammalian PLCbeta(1), which localizes in the nucleus, is activated in insulin-like growth factor 1-mediated...

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PMID: 10913438
DOI: 10.1074/jbc.M004630200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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