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Article

AGO4 regulates entry into meiosis and influences silencing of sex chromosomes in the male mouse germline.

Developmental cell - 14 Aug 2012

Modzelewski Andrew J, Holmes Rebecca J, Hilz Stephanie, Grimson Andrew, Cohen Paula E

Abstract excerpt

The four mammalian Argonaute family members are thought to share redundant functions in the microRNA pathway, yet only AGO2 possesses the catalytic "slicer" function required for RNAi. Whether AGO1, AGO3, or AGO4 possesses specialized functions remains unclear. Here we show that AGO4 localizes to spermatocyte nuclei during meiotic prophase I, specifically at sites of asynapsis and the transcriptionally silenced...

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Topics

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Share to Apoptosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22863743
DOI: 10.1016/j.devcel.2012.07.003
PMCID: PMC3470808

Genes

AGO4
AGO1
AGO2
AGO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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