Article
Relationship between cyclooxygenase 8473T>C polymorphism and the risk of lung cancer: a case-control study.
BMC cancer - 17 Mar 2006
Park Jung Min, Choi Jin Eun, Chae Myung Hwa, Lee Won Kee, Cha Sung Ick, Son Ji-Woong, Kim Chang Ho, Kam Sin, Kang Young Mo, Jung Tae Hoon, Park Jae Yong
Abstract excerpt
BACKGROUND: Cyclooxygenase-2 (COX-2) plays an important role in the development of lung cancer. DNA sequence variations in the COX-2 gene may lead to altered COX-2 production and/or activity, and so they cause inter-individual differences in the susceptibility to lung cancer. To test this hypothesis, we investigated the association between the 8473T>C polymorphism in the 3'-untranslated region of the COX-2 gene...
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