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Article

The effects of RNA degradation enzymes on antisense RNAI controlling ColE2 plasmid copy number.

Plasmid - 1 Nov 2008

Nishio Shin-ya, Itoh Tateo

Abstract excerpt

Replication of the ColE2 plasmid requires a plasmid-coded initiator protein (Rep). Rep expression is controlled by antisense RNA (RNAI), which prevents the Rep mRNA translation. In this paper, we examined the effects of RNA degradation enzymes on the degradation pathways of RNAI of the ColE2 plasmid. In the DeltapcnB strain lacking the poly(A) polymerase I (PAP I) the RNAI degradation intermediate (RNAI(*))...

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Identifiers

PMID: 18687357
DOI: 10.1016/j.plasmid.2008.07.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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The effects of RNA degradation enzymes on antisense RNAI controlling ColE2 plasmid copy number.PMID 18687357Read ↗

Replication initiator protein mRNA of ColE2 plasmid and its antisense regulator RNA are under the control of different degradation pathways.Semantic proximity Read ↗

Control of ColE2 plasmid replication: regulation of Rep expression by a plasmid-coded antisense RNA.Semantic proximity Read ↗

Control of ColE2 DNA replication: in vitro binding of the antisense RNA to the Rep mRNA.Semantic proximity Read ↗

Degradation pathway of CopA, the antisense RNA that controls replication of plasmid R1.Semantic proximity Read ↗

Absence of RNASE III alters the pathway by which RNAI, the antisense inhibitor of ColE1 replication, decays.Semantic proximity Read ↗

Regulation of plasmid R1 replication: PcnB and RNase E expedite the decay of the antisense RNA, CopA.Semantic proximity Read ↗

Importance of the leader region of mRNA for translation initiation of ColE2 Rep protein.Semantic proximity Read ↗

The Escherichia coli pcnB gene promotes adenylylation of antisense RNAI of ColE1-type plasmids in vivo and degradation of RNAI decay intermediates.Semantic proximity Read ↗

Control of replication of plasmid R1: the duplex between the antisense RNA, CopA, and its target, CopT, is processed specifically in vivo and in vitro by RNase III.Semantic proximity Read ↗

Control of replication of plasmid R1: the intergenic region between copA and repA modulates the level of expression of repA.Semantic proximity Read ↗

Modulation of ColE1-like plasmid replication for recombinant gene expression.Semantic proximity Read ↗

Origin-specific reduction of ColE1 plasmid copy number due to mutations in a distinct region of the Escherichia coli RNA polymerase.Semantic proximity Read ↗

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