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Article

Specific mutations within the AT-rich region of a plasmid replication origin affect either origin opening or helicase loading.

Proceedings of the National Academy of Sciences of the United States of America - 12 Aug 2008

Rajewska Magdalena, Kowalczyk Lukasz, Konopa Grazyna, Konieczny Igor

Abstract excerpt

Prokaryotic and eukaryotic replicons possess a distinctive region containing a higher than average number of adenine and thymine residues (the AT-rich region) where, during the process of replication initiation, the initial destabilization (opening) of the double helix takes place. In many prokaryotic origins, this region consists of repeated 13-mer motifs whose function has not yet been specified. Here we...

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Identifiers

PMID: 18685104
DOI: 10.1073/pnas.0805662105
PMCID: PMC2516259

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