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Article

PERK controls bone homeostasis through the regulation of osteoclast differentiation and function

13 Oct 2020

Abstract excerpt

Osteoclasts are multinucleated giant cells with the ability to degrade bone tissue, and are closely related to abnormal bone metabolic diseases. Endoplasmic reticulum (ER) is an organelle responsible for protein modification, quality control, and transportation. The accumulation of unfolded or misfolded proteins in ER cavity induces ER stress. Double-stranded RNA-dependent protein kinase-like ER kinase (PERK) is...

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PMID: 33051453
DOI: 10.1038/s41419-020-03046-z

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