Article

Intestinal cell kinase regulates chondrocyte proliferation and maturation during skeletal development

2017-05-17

Abstract excerpt

An autosomal recessive loss-of-function mutation R272Q in human ICK (intestinal cell kinase) gene causes profound multiplex developmental defects in human ECO (endocrine-cerebro-osteodysplasia) syndrome. ECO patients exhibit a wide variety of skeletal abnormalities, yet the underlying cellular and molecular mechanisms by which ICK regulates skeletal development remain largely unknown. The goal of this study is to...

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Literature Corpus work: 8ed21493-6ace-5aa1-92f0-e24dd74cbdaf
DOI: 10.1101/139089

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