Article

Mesenchymal expression of activated K-ras yields Noonan Syndrome-like bone defects that are rescued by mid-gestational MEK inhibition

2019-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Activating germline K-ras mutations cause Noonan syndrome (NS), which is characterized by several developmental deficits including cardiac defects, cognitive delays and skeletal abnormalities. NS patients have increased signaling through the MAPK pathway. To model NS skeletal defects and understand the effect of hyperactive K-ras signaling on normal limb development, we generated a mouse model i...

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Literature Corpus work: 3e577dc8-8d38-57c4-903e-a19d4ba32376
DOI: 10.1101/634840

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