Article

PERK inhibition with GSK2606414 in zebrafish evokes developmental defects consistent with Wolcott-Rallison syndrome phenotypes

2024-04-20

Abstract excerpt

<h4>Background</h4> PERK (EIF2AK3) is an endoplasmic reticulum stress kinase whose loss of function disturbs human development, leading to skeletal dysplasia and permanent neonatal diabetes, as observed in the Wolcott-Rallison Syndrome (WRS). The lack of effective, less invasive therapies for developmental diseases highlights the need for animal models that replicate complex pathological phenotypes, while allowin...

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Literature Corpus work: bea8542a-8427-5a14-939b-0cbfa2e3d349
DOI: 10.1101/2024.04.16.589737

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