Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine.

doi:10.1007/BF00279968

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Article

Genetic analysis of the interethnic difference between Chinese and Caucasians in the polymorphic metabolism of debrisoquine and codeine.

European journal of clinical pharmacology - 1 Jan 1991

Johansson I, Yue Q Y, Dahl M L, Heim M, Säwe J, Bertilsson L, Meyer U A, Sjöqvist F, Ingelman-Sundberg M

Abstract excerpt

The Far Eastern and Caucasian populations are strikingly different with respect to the debrisoquine/sparteine hydroxylation polymorphism. The number of poor metabolizers, as defined for Caucasians, is very low among Chinese and Japanese. We investigated the molecular basis for this difference by analysis of the CYP2D6 gene in 115 Chinese subjects, combined with phenotypic classification of codeine and...

Topics

Adolescent
Adult
Alleles
Asian People
Blotting, Southern
China
Codeine
Cytochrome P-450 Enzyme System
Debrisoquin
Female
Gene Amplification

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Hydroxylation

Japan

Male

Metabolic Clearance Rate

Middle Aged

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1679392
DOI: 10.1007/BF00279968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1679392-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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