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Article

Association of a polymorphism near CREB1 with differential aversion processing in the insula of healthy participants.

Archives of general psychiatry - 1 Aug 2008

Perlis Roy H, Holt Daphne J, Smoller Jordan W, Blood Anne J, Lee Sang, Kim Byoung Woo, Lee Myung Joo, Sun Mei, Makris Nikos, Kennedy David K, Rooney Kathryn, Dougherty Darin D, Hoge Rick, Rosenbaum Jerrold F, Fava Maurizio, Gusella James, Gasic Gregory P, Breiter Hans C

Abstract excerpt

CONTEXT: Previous functional neuroimaging studies have identified a network of brain regions that process aversive stimuli, including anger. A polymorphism near the cyclic adenosine monophosphate response element binding protein gene (CREB1) has recently been associated with greater self-reported effort at anger control as well as risk for antidepressant treatment-emergent suicidality in men with major depressive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18678793
DOI: 10.1001/archgenpsychiatry.2008.3
PMCID: PMC3782742

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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