COMT Val158Met polymorphism influences the susceptibility to framing in decision-making: OFC-amygdala functional connectivity as a mediator.

doi:10.1002/hbm.23142

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Article

COMT Val158Met polymorphism influences the susceptibility to framing in decision-making: OFC-amygdala functional connectivity as a mediator.

Human brain mapping - 1 May 2016

Gao Xiaoxue, Gong Pingyuan, Liu Jinting, Hu Jie, Li Yue, Yu Hongbo, Gong Xiaoliang, Xiang Yang, Jiang Changjun, Zhou Xiaolin

Abstract excerpt

Individuals tend to avoid risk in a gain frame, in which options are presented in a positive way, but seek risk in a loss frame, in which the same options are presented negatively. Previous studies suggest that emotional responses play a critical role in this "framing effect." Given that the Met allele of COMT Val158Met polymorphism (rs4680) is associated with the negativity bias during emotional processing, this...

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PMID: 26917235
DOI: 10.1002/hbm.23142
PMCID: PMC6867526

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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