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Article

Independent modulation of engagement and connectivity of the facial network during affect processing by CACNA1C and ANK3 risk genes for bipolar disorder.

JAMA psychiatry - 1 Dec 2013

Dima Danai, Jogia Jigar, Collier David, Vassos Evangelos, Burdick Katherine E, Frangou Sophia

Abstract excerpt

IMPORTANCE: Genome-wide association studies (GWASs) indicate that single-nucleotide polymorphisms in the CACNA1C and ANK3 genes increase the risk for bipolar disorder (BD). The genes influence neuronal firing by modulating calcium and sodium channel functions, respectively. Both genes modulate γ-aminobutyric acid-transmitting interneuron function and can thus affect brain regional activation and interregional...

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Source

Identifiers

PMID: 24108394
DOI: 10.1001/jamapsychiatry.2013.2099

Genes

ANK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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