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Article

Clinical and genetic dissection of anger expression and CREB1 polymorphisms in major depressive disorder.

Biological psychiatry - 1 Sept 2007

Perlis Roy H, Purcell Shaun, Fagerness Jesen, Cusin Cristina, Yamaki Lesley, Fava Maurizio, Smoller Jordan W

Abstract excerpt

BACKGROUND: Anger and irritability are prominent in a subset of individuals with major depressive disorder (MDD). Phosphorylation of the transcription factor cyclic adenosine monophosphate (cAMP) Response Element Binding Protein (CREB) has been associated with aggression or reward/aversion in rodents, and markers near CREB1 have been linked to MDD. Therefore, we examined the association between CREB1...

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Identifiers

PMID: 17300755
DOI: 10.1016/j.biopsych.2006.10.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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