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Article

Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.

Cell cycle (Georgetown, Tex.) - 1 Aug 2008

Park Yoonsoo, Kubo Akihito, Komiya Takefumi, Coxon Amy, Beebe Kristin, Neckers Len, Meltzer Paul S, Kaye Frederic J

Abstract excerpt

Certain kindreds with low-penetrant (lp) retinoblastoma carry mutant alleles which retain partial tumor suppressor activity and we previously showed that these alleles exhibit defective, temperature-sensitive binding in yeast. To investigate the molecular basis for incomplete penetrance, we studi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18677112
DOI: 10.4161/cc.6363
PMCID: PMC2562607

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-18677112-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

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Low-penetrant RB allele in small-cell cancer shows geldanamycin instability and discordant expression with mutant ras.PMID 18677112Read ↗

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Oncogenic point mutations in exon 20 of the RB1 gene in families showing incomplete penetrance and mild expression of the retinoblastoma phenotype.Semantic proximity Read ↗

p53 mutants exhibiting enhanced transcriptional activation and altered promoter selectivity are revealed using a sensitive, yeast-based functional assay.Semantic proximity Read ↗

Selective functional inhibition of a tumor-derived p53 mutant by cytosolic chaperones identified using split-YFP in budding yeastSemantic proximity Read ↗

Partial inactivation of the RB product in a family with incomplete penetrance of familial retinoblastoma and benign retinal tumors.Semantic proximity Read ↗

The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.Semantic proximity Read ↗

Functional analysis at the Cys706 residue of the retinoblastoma protein.Semantic proximity Read ↗

Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation.Semantic proximity Read ↗

A single amino acid substitution results in a retinoblastoma protein defective in phosphorylation and oncoprotein binding.Semantic proximity Read ↗

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