Article
The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent.
Molecular and cellular biology - 1 Mar 1998
Whitesell L, Sutphin P D, Pulcini E J, Martinez J D, Cook P H
Abstract excerpt
Wild-type p53 is a short-lived protein which turns over very rapidly via selective proteolysis in the ubiquitin-proteasome pathway. Most p53 mutations, however, encode for protein products which display markedly increased intracellular levels and are associated with positive tumor-promoting activity. The mechanism by which mutation leads to impairment of ubiquitination and proteasome-mediated degradation is...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.