Article
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.
Genes & development - 1 Aug 2008
Schotta Gunnar, Sengupta Roopsha, Kubicek Stefan, Malin Stephen, Kauer Monika, Callén Elsa, Celeste Arkady, Pagani Michaela, Opravil Susanne, De La Rosa-Velazquez Inti A, Espejo Alexsandra, Bedford Mark T, Nussenzweig André, Busslinger Meinrad, Jenuwein Thomas
Abstract excerpt
H4K20 methylation is a broad chromatin modification that has been linked with diverse epigenetic functions. Several enzymes target H4K20 methylation, consistent with distinct mono-, di-, and trimethylation states controlling different biological outputs. To analyze the roles of H4K20 methylation states, we generated conditional null alleles for the two Suv4-20h histone methyltransferase (HMTase) genes in the...
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