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Article

H4K20 monomethylation inhibition causes loss of genomic integrity in mouse preimplantation embryos.

The Journal of reproduction and development - 13 Oct 2020

Shikata Daiki, Yamamoto Takuto, Honda Shinnosuke, Ikeda Shuntaro, Minami Naojiro

Abstract excerpt

Maintaining genomic integrity in mammalian early embryos, which are deficient in DNA damage repair, is critical for normal preimplantation and subsequent development. Abnormalities in DNA damage repair in preimplantation embryos can cause not only developmental arrest, but also diseases such as congenital disorders and cancers. Histone H4 lysine 20 monomethylation (H4K20me1) is involved in DNA damage repair and...

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Identifiers

PMID: 32378528
DOI: 10.1262/jrd.2020-036
PMCID: PMC7593633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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