Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.

Cellular signalling - 1 Nov 2008

Abe Takuya, Ishiai Masamichi, Hosono Yoshifumi, Yoshimura Akari, Tada Shusuke, Adachi Noritaka, Koyama Hideki, Takata Minoru, Takeda Shunichi, Enomoto Takemi, Seki Masayuki

Abstract excerpt

KU70(-/-) and DNA-PKcs(-/-/-)chicken DT40 cells are reportedly highly sensitive to the DNA topoisomerase II inhibitor etoposide. Here we report that KU70 and DNA-PKcs unexpectedly function together during the induction of apoptosis after exposure to high levels of etoposide. In the presence of 100 microM etoposide, apoptosis was induced within 1 h in wild type DT40 cells but not in KU70(-/-) and DNA-PKcs(-/-/-)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Nuclear
Share to Cell Survival

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chickens

Share to Chromatin

Share to DNA-Activated Protein Kinase

Share to DNA Breaks, Double-Stranded

Share to Etoposide

Share to Ku Autoantigen

Source

Identifiers

PMID: 18674614
DOI: 10.1016/j.cellsig.2008.07.006

Genes

LIG4
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.PMID 18674614Read ↗

Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand BreaksSemantic proximity Read ↗

Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.Semantic proximity Read ↗

Genetic evidence for involvement of two distinct nonhomologous end-joining pathways in repair of topoisomerase II-mediated DNA damage.Semantic proximity Read ↗

Parp-1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells.Semantic proximity Read ↗

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joiningSemantic proximity Read ↗

Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.Semantic proximity Read ↗

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complexSemantic proximity Read ↗

AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cellsSemantic proximity Read ↗

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombinationSemantic proximity Read ↗

Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA EndsSemantic proximity Read ↗

Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated and Artemis for their repairSemantic proximity Read ↗

Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.