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Article

Synergy between Prkdc and Trp53 regulates stem cell proliferation and GI-ARS after irradiation.

Cell death and differentiation - 1 Nov 2017

Gurley Kay E, Ashley Amanda K, Moser Russell D, Kemp Christopher J

Abstract excerpt

Ionizing radiation (IR) is one of the most widely used treatments for cancer. However, acute damage to the gastrointestinal tract or gastrointestinal acute radiation syndrome (GI-ARS) is a major dose-limiting side effect, and the mechanisms that underlie this remain unclear. Here we use mouse models to explore the relative roles of DNA repair, apoptosis, and cell cycle arrest in radiation response. IR induces DNA...

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Identifiers

PMID: 28686579
DOI: 10.1038/cdd.2017.107
PMCID: PMC5635213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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