Article
Two distinct pathways of cell death triggered by oxidative damage to nuclear and mitochondrial DNAs.
The EMBO journal - 23 Jan 2008
Oka Sugako, Ohno Mizuki, Tsuchimoto Daisuke, Sakumi Kunihiko, Furuichi Masato, Nakabeppu Yusaku
Abstract excerpt
Oxidative base lesions, such as 8-oxoguanine (8-oxoG), accumulate in nuclear and mitochondrial DNAs under oxidative stress, resulting in cell death. However, it is not known which form of DNA is involved, whether nuclear or mitochondrial, nor is it known how the death order is executed. We established cells which selectively accumulate 8-oxoG in either type of DNA by expression of a nuclear or mitochondrial form...
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