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Article

DNA-PKcs and Artemis function in the end-joining phase of immunoglobulin heavy chain class switch recombination

3 Mar 2008

Abstract excerpt

The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and Artemis are classical nonhomologous DNA end-joining (C-NHEJ) factors required for joining a subset of DNA double-strand breaks (DSB), particularly those requiring end processing. In mature B cells, activation-induced cytidine deaminase (AID) initiates class switch recombination (CSR) by introducing lesions into S regions upstream of two recombining...

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PMID: 18316419
DOI: 10.1084/jem.20080044

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