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Article

Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.

Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2005

Rooney Sean, Alt Frederick W, Sekiguchi JoAnn, Manis John P

Abstract excerpt

Assembly of Ig genes in B lineage cells involves two distinct DNA rearrangements. In early B cell development, site-specific double strand breaks (DSBs) at germ-line V, D, and J gene segments are joined via nonhomologous end-joining (NHEJ) to form variable region exons. Activated mature B cells c...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15699324
DOI: 10.1073/pnas.0409857102
PMCID: PMC548986

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15699324-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Artemis-independent functions of DNA-dependent protein kinase in Ig heavy chain class switch recombination and development.PMID 15699324Read ↗

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