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Article

AKT2 suppresses pro-survival autophagy triggered by DNA double-strand breaks in colorectal cancer cells

24 Aug 2017

Abstract excerpt

DNA double-strand breaks (DSBs) are critical DNA lesions, which threaten genome stability and cell survival. DSBs are directly induced by ionizing radiation (IR) and radiomimetic agents, including the cytolethal distending toxin (CDT). This bacterial genotoxin harbors a unique DNase-I-like endonuclease activity. Here we studied the role of DSBs induced by CDT and IR as a trigger of autophagy, which is a cellular...

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PMID: 28837154
DOI: 10.1038/cddis.2017.418

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