Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA Ends

21 Jul 2006

Abstract excerpt

Repair of DNA double strand breaks (DSB) by the nonhomologous end-joining pathway in mammals requires at least seven proteins involved in a simplified two-step process: (i) recognition and synapsis of the DNA ends dependent on the DNA-dependent protein kinase (DNA-PK) formed by the Ku70/Ku80 heterodimer and the catalytic subunit DNA-PKcs in association with Artemis; (ii) ligation dependent on the DNA ligase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16857680
DOI: 10.1074/jbc.m603047200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interplay between Ku, Artemis, and the DNA-dependent Protein Kinase Catalytic Subunit at DNA EndsPMID 16857680Read ↗

The DNA‐dependent protein kinase: the director at the endSemantic proximity Read ↗

Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand BreaksSemantic proximity Read ↗

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joiningSemantic proximity Read ↗

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complexSemantic proximity Read ↗

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcsSemantic proximity Read ↗

DNA-dependent protein kinase promotes DNA end processing by MRN and CtIPSemantic proximity Read ↗

Differential role of nonhomologous end joining factors in the generation, DNA damage response, and myeloid differentiation of human induced pluripotent stem cells.Semantic proximity Read ↗

Non‐homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair processSemantic proximity Read ↗

DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?Semantic proximity Read ↗

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaksSemantic proximity Read ↗

Proofreading activity of DNA polymerase Pol2 mediates 3'-end processing during nonhomologous end joining in yeast.Semantic proximity Read ↗

DNA-dependent Protein Kinase and XRCC4-DNA Ligase IV Mobilization in the Cell in Response to DNA Double Strand BreaksSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.